The TechImmune genes as components of a superior next-generation SARS-CoV-2 vaccine, have strong potential to provide broader and more durable protection against variants of concern compared to the standard of care spike-only vaccines. In addition, such a vaccine could be an integral part of a combination vaccine to target multiple respiratory pathogens, such as influenza and RSV, in a single product.
TechImmune is advancing in the development of a next-generation, broad-spectrum COVID vaccine, designed to negate the necessity for recurrent boosters that characterize existing vaccines. This innovative formulation adopts a multi-antigen strategy to elicit a comprehensive immune response, involving both antibody and T cell activation. Contrasting with conventional vaccines that primarily utilize the Spike protein to induce neutralizing antibodies, TechImmune's Coronavirus vaccine encompasses a more advanced approach, targeting antigens to enhance lasting immunity. Step beyond traditional boundaries with TechImmune.
Develop and commercialize a next-generation broad-spectrum Covid vaccine to protect the public and economic health of individuals and societies globally.``INVEST IN A BETTER TOMORROW``Contact Us
Despite the rapid introduction of safe and effective vaccines and therapeutics to combat COVID-19, the pandemic continues to rage worldwide. These vaccines and therapeutics have slowed the progression of the pandemic and blunted the severity of disease, but it has become very clear that the current standard of care is not a long-term solution to the problem, underscoring the desperate need for better medical interventions. TechImmune is developing a next-generation, broad-spectrum covid vaccine that confers potent and broad immunity to provide a long-term solution to current and future outbreaks of CoV. This vaccine could be implemented as a booster of choice and to prevent potential future pandemics.
OUR LEADERSHIP TEAM
Mr. Herbert has spent over 50 years in the pharmaceutical industry. He is the co-founder of Allergan Inc., CEO and Chairman of the Board for 30 years. Mr. Herbert served as Executive Vice President of SmithKline Beckman. He received his B.S. in Business, from the University of Southern California.
Jeffrey Ulmer, PhD
CEO and Board Member
Dr. Ulmer has >30 years of experience in Vaccines R&D and most recently served as the Global Head of External Research at Novartis and the Head of Preclinical R&D US at GSK Vaccines. Specialties: Biochemistry, Immunology and Cell Biology. Dr. Ulmer received his PhD from McGill University and post-doctoral fellowship at Yale University School of Medicine.
CFO and Board Member
Mr. Haugen was the CEO and President of a public firm, Amylin Pharmaceuticals. He spent 17 years with Allergan Inc. of Irvine culminating that career as Chief Operating Officer of the billion plus global company. He received his B.S. and MBA from the University of Southern California.
Lbachir BenMohamed, PhD
Vice President and Board Member
In 2002, Dr. BenMohamed founded the Cellular & Molecular Immunology Laboratory at UC Irvine. He is the lead investigator for Techlmmune. He is a recipient of several United States National Institute of Health (NIH) grants. He completed his PhD in Immunology at the Pasteur Institute, Paris, France.
Dan Gil, PhD
COO and Board Member
Dr. Gil has had a 30+year career in Pharmaceutical R&D as VP of Research at Allergan. Dr. Gil has an undergraduate degree in Biology from Harvard University and a PhD in Pharmacology from University of Pennsylvania.
Dr. Trevor Jones CBE, PhD, DsC
Former Head of Research for Burroughs Welcome, UK for over 20 years. Served as Head of British Pharmaceutical Association. He has been an advisor to the UK Government and G7 pandemic preparedness “100” days initiatives
to develop diagnostics, vaccines, and therapeutics for global use.
James Cavanaugh, PhD
Dr. Cavanaugh is a Managing Director and Senior Advisor to HealthCare Venture LLC, a private equity and venture capital firm specializing in early stage biotechnology investments. He was previously President of SmithKline & French. He also served as President of Allergan International. Dr. Cavanaugh received his B.S. from Farleigh Dickinson University, M.A. and his Ph.D. from University of Iowa.
Current Situation and Future Needs
Since early 2020, a deadly pandemic caused by a new Coronavirus (SARS-CoV-2) has threatened public health, world economies, and quality of life on a global scale. As of January 2023, the COVID-19 outbreak has resulted in >669 million confirmed cases and >6.7 million deaths worldwide (https://coronavirus.jhu.edu/map.html).
Unlike the previous CoV outbreaks, which were successfully managed using public health measures, containment of SARS-CoV-2 will require a concerted effort involving vaccines and therapeutics, along with public health measures. While the successes with first generation of CoV vaccines have been remarkable, it is becoming clear that a better and long-term solution to end the current pandemic and prevent future outbreaks is desperately needed.
During the COVID-19 outbreak, mutations and deletions in the Spike protein gene have produced a succession of fast spreading and pathogenic SARS-CoV-2 variants of concern (VOCs) with the potential to escape vaccine-induced immunity. Despite the deployment of >13 billion doses of CoV vaccine worldwide, >15 million new cases of COVID-19 were reported during the month of December 2022 alone (https://coronavirus.jhu.edu/map.html). These stark numbers emphasize the need for a superior, next-generation vaccine that induces broad-based, cross-reactive, and long-lasting immunity.
In January the Food & Drug Administration (FDA) announced a recommendation that future generation vaccines should be given on an annual basis. This certainly confirms the belief of the scientific community that COVID with will be with us for a long time.
Vaccines were initially very effective at conferring protective immunity through the induction of neutralizing antibodies directed against spike protein. However, real-world data collected since deployment of the vaccines has demonstrated waning immunity over time and emergence of viral variants of concern (VOC) containing mutations in the spike protein with potential to escape vaccine-induced immunity. Hence, there is a pressing need to move beyond a narrow focus of immunity directed against a single viral antigen.
In order to create a pre-emptive universal Coronavirus vaccine, effective against all coronavirus variants – future, current, and past – TechImmune is developing a broad-spectrum vaccine targeting spike plus other more conserved antigens to elicit both neutralizing antibodies and cross-strain T cell responses.
GRANTS and CONTRACTS
In February 2023, TechImmune, LLC was awarded a business (SBIR) grant from the U.S. National Institute of Allergy and Infectious Diseases (NIH) to develop a Universal Vaccine Against Multiple Coronavirus Variants of Concern.
Additional grants pending Spring 2023.
TechImmune has an exclusive license agreement that covers 6 patent applications. Future government grants are pending in the current year.
TechImmune continues to raise additional funding with a Strike Stock Series B investment round in 1st Q23.